Bis(5'-adenosyl)-triphosphatase

Bis(5'-adenosyl)-triphosphatase is a hydrolase enzyme that catalyzes the cleavage of nucleoside triphosphate analogs, specifically hydrolyzing A-5'-PPP-5'A (a dinucleoside triphosphate) to AMP and ADP. Its gene, FHIT, is frequently referred to as a tumor suppressor in specific tissues and may have a role in preventing cancer development. The protein binds Nickel cations, operates in the cytoplasm, and is classified functionally as a catalytic enzyme in nucleotide metabolism, with additional possible roles in tumor suppression, though its protein type is sometimes listed as "unknown" in some protein databases[2][8]. There are no current drugs that target this enzyme, and it is not commonly used as a clinical biomarker at this time. Caveats: The name "Bis-triphosphatase" is slightly ambiguous, as it omits the specific substrates; the canonical enzyme is "Bis(5'-adenosyl)-triphosphatase," and broader "bisphosphatase" or "triphosphatase" enzymes can describe different activities (e.g., fructose bisphosphatases in glycolysis, see [3], but these are completely distinct molecular entities)[3][5][7]. The information here is specific to the bis(5'-adenosyl)-triphosphatase and its FHIT gene product, matching standard usage in major biomedical databases[2][8]. If you are seeking information on a non-nucleotide "bis-triphosphatase," such as one involved in central metabolism (e.g., fructose-1,6-bisphosphatase), re-specification would be required. Otherwise, all information maps to the nucleotide hydrolase, bis(5'-adenosyl)-triphosphatase.

Other names

Bis(5'-adenosyl)-triphosphataseFHIT