Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) (NUDT2)

Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical), commonly referred to as **NUDT2**, is an enzyme and member of the NUDIX hydrolase family. It asymmetrically hydrolyzes diadenosine 5',5'''-tetraphosphate (Ap4A) to produce AMP and ATP, helping to maintain intracellular Ap4A concentrations, which are implicated in cellular stress signaling and cell cycle regulation[3][4]. NUDT2 also removes 5'-phosphates from viral PPP-RNA, initiating its degradation and thus serving a role in antiviral immunity[1]. In cancer, notably triple negative breast cancer, NUDT2 is upregulated and associated with increased proliferation, migration, invasion, and anchorage-independent growth, positioning it as a potential therapeutic target as well as a prognostic biomarker for certain malignancies[2].

Other names

Nudix hydrolase 2APAH1Ap4A hydrolaseAp4AaseDiadenosine tetraphosphataseNudix motif 2Diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolaseNucleoside diphosphate-linked moiety X motif 2Ap4A hydrolase 1Diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolaseMutT motif protein 2

Enzymatic hydrolysis of Ap4A to AMP and ATP Removal of 5′-phosphates from PPP-RNA for exonuclease-mediated viral RNA degradation