Blood coagulation factor (None (individual factors abbreviated as e.g., FII, FVIII))

Blood coagulation factor Overview

Clotting factor" is a generic, non-canonical term describing a group of at least 13 (often numbered I–XIII) *proteins and cofactors in blood plasma* that act sequentially in the coagulation cascade to form blood clots[1][3][7]. These include both **serine proteases** (e.g., thrombin—Factor IIa, Factor Xa, Factor IXa) and **non-enzymatic cofactors** (e.g., Factor V, Factor VIII), as well as calcium ions and tissue factor[1][7]. Deficiency or dysfunction of specific clotting factors underlies bleeding disorders such as hemophilia A (FVIII) and hemophilia B (FIX)[1][6][7]. Overactivity or resistance can lead to thrombosis (clot formation within vessels)[7]. Numerous anticoagulant drugs act by targeting specific clotting factors, either inhibiting them directly (heparin, direct oral anticoagulants) or by affecting their synthesis (warfarin, vitamin K antagonists)[5][7]. Measurement of individual factor concentrations and activity is used as a biomarker for diagnosis and management of various bleeding and thrombotic disorders[3][7]. Since "clotting factor" is not a specific protein or receptor, but a class, it should be replaced with the precise factor of interest for structured data work. **Note:** - “Clotting factor” is not a unique molecule but a class comprising multiple distinct proteins, ions, and cofactors each with specific roles and names (e.g., “Factor VIII,” “Factor Xa,” “Fibrinogen”). - For structured information, use the full name of the specific factor (e.g., "Coagulation factor VIII") instead of the generic "clotting factor."[1][3][7] - This answer reflects the plural, imprecise nature of the target as provided and marks `is_incorrect: true` for database use.

Mechanism of Action

Inhibition (anticoagulants inhibit one or more factors), Replacement/augmentation (factor concentrates), Vitamin K antagonism (warfarin), Protease inhibition (heparin enhances antithrombin’s inhibition)

Biological Functions

Safety Considerations

Interacting Drugs

Associated Biomarkers