Coagulation factor

Coagulation factors are a group of plasma proteins essential for the normal process of blood clotting (coagulation) and hemostasis[1][2][3]. Deficiency or dysfunction of one or more coagulation factors leads to bleeding disorders such as hemophilia A (factor VIII deficiency), hemophilia B (factor IX deficiency), and von Willebrand disease. Therapeutic replacement of deficient or dysfunctional coagulation factors is accomplished with plasma, cryoprecipitate, or purified factor concentrates to restore the integrity of the coagulation cascade and achieve hemostasis[5][7]. This mechanism underlies most treatments for acute or chronic bleeding due to congenital or acquired coagulopathies. Coagulation factor transfusions can be associated with safety concerns, particularly with plasma-derived products, including risks of transfusion-transmitted infection, allergic reactions, and thrombosis.

Other names

Clotting factorBlood coagulation factorPlasma coagulation factor

Factor replacement, Enzymatic catalysis of clot formation, Promotion of thrombin generation, Restoration of deficient step in coagulation cascade