BOC cell adhesion associated, oncogene regulated (BOC)

BOC cell adhesion associated, oncogene regulated (BOC) is a transmembrane cell-surface receptor that belongs to the immunoglobulin/fibronectin type III repeat family[4][5]. BOC acts as a coreceptor for Hedgehog (HH) ligands and is involved in the modulation of Hedgehog signaling, a pathway critical for embryonic development, neural patterning, myogenic differentiation, and craniofacial development[2][4]. Expressed highly in developing and some adult tissues—including articular cartilage and neuronal populations—BOC mediates cell-cell interactions and forms complexes with the related receptor CDON, as well as participating synergistically with other proteins like GAS1. Dysregulation or genetic loss of BOC function can result in developmental abnormalities including craniofacial defects and disordered neural patterning. While a promising candidate for study in cancer and developmental biology, BOC is not currently a direct therapeutic target of any drug, and no established pharmacological modulators are in clinical use[5].

Other names

Brother of CDOBoiCDON2Protein BOCbrother of CDONUNQ604/PRO1190Boc homologcell adhesion associated, oncogene regulated 2