Bone morphogenetic protein receptor type-1A (BMPR1A), Bone morphogenetic protein receptor type-1B (BMPR1B), Bone morphogenetic protein receptor type II (BMPR2) (BMPR1A, BMPR1B, BMPR2)

Bone morphogenetic protein receptors (BMPRs) are transmembrane serine/threonine kinase receptors in the TGF-beta receptor superfamily that mediate the cellular effects of bone morphogenetic proteins (BMPs). There are two main types: type I receptors (BMPR1A, BMPR1B) and type II receptor (BMPR2). Ligand binding results in the formation of a heteromeric complex between type II and type I receptors, with type II receptors phosphorylating and activating type I receptors, which in turn propagate signals via SMAD transcription factors. These receptors play crucial roles in embryogenesis, tissue homeostasis, bone and cartilage development, stem cell differentiation, and tumor suppression. Genetic mutations in these genes are linked to diseases such as juvenile polyposis syndrome, various cancers, and skeletal malformations.

Other names

BMPR-IA (BMPR1A)CD292 (BMPR1A)BMP receptor type IABMP receptor type IBBMPR-IIBMPR2

Ligand (BMPs) binding causes the formation of a receptor complex (type I and type II receptors) leading to phosphorylation of type I receptor by the constitutively active type II receptor. Signal proceeds through the SMAD pathway, affecting gene transcription.