Molecular Classification
Serine/threonine kinase receptor, Type I BMP receptor, Transmembrane receptor
Other Names
CDw293
Disease Roles
Primary pulmonary hypertensionSkeletal malformations

Bone morphogenetic protein receptor type 1B Overview

Bone morphogenetic protein receptor type 1B (BMPR1B) is a transmembrane serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). BMPs are part of the transforming growth factor-beta (TGF-β) superfamily and play critical roles in embryogenesis, endochondral bone formation, and various cellular differentiation processes. BMPR1B mediates signals from BMP ligands involved in endochondral bone formation, embryonic development, neural differentiation, and formation of middle and proximal phalanges. Mutations in BMPR1B have been linked to primary pulmonary hypertension and skeletal malformations.

Mechanism of Action

BMPR1B functions as a receptor for BMPs, forming a heteromeric complex with type II BMP receptors upon ligand binding. This leads to phosphorylation of SMAD proteins and activation of MAPK pathways, ultimately regulating gene expression.

Biological Functions

Signal transduction
Endochondral bone formation
Embryonic development
Neural differentiation
Chondrogenesis
Regulation of gene expression

Disease Associations

Primary pulmonary hypertension
Skeletal malformations

Safety Considerations

  • Overactive BMP signaling can lead to various diseases.
  • Small molecule inhibitors targeting BMP kinases need careful consideration of potential off-target effects.