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Target intelligence / Profile preview
Bone morphogenetic protein receptor type-1B (BMPR1B)
- Target
- BMPR1B
- Molecular classification
- Receptor, Serine/threonine kinase, Type I BMP receptor, Activin receptor-like kinase (ALK)
01
Overview
Bone morphogenetic protein receptor type-1B (BMPR1B) is a transmembrane serine/threonine kinase receptor for bone morphogenetic proteins (BMPs). It plays a critical role in embryogenesis, endochondral bone formation, and various cellular differentiation processes. Upon ligand binding, BMPR1B initiates intracellular signaling by phosphorylating SMAD effectors or activating non-canonical pathways such as MAPK. Mutations or dysregulation of BMPR1B have been linked with several human diseases, including primary pulmonary hypertension, acromesomelic dysplasia-type 3, and brachydactyly.
- Other names
- CDw293ALK6Activin receptor-like kinase 6
02
Mechanism of action
Not applicable, as no specific drugs are mentioned in the context information that directly target this molecule.
03
Biological functions
Signal transductionEndochondral ossificationEmbryonic developmentSkeletal developmentChondrogenesisRegulation of gene expression
04
Disease associations
Primary pulmonary hypertensionAcromesomelic dysplasia-type 3Brachydactyly
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