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Target intelligence / Profile preview
Bordetella pertussis (attenuated live bacteria) (B. pertussis (attenuated))
- Target
- B. pertussis (attenuated)
- Molecular classification
- Bacteria, Vaccine component, Live attenuated vaccine
01
Overview
Attenuated live Bordetella pertussis bacteria serve as a vaccine to prevent whooping cough. The attenuated strain stimulates a robust immune response without causing severe disease, mimicking a natural infection to generate long-lasting immunity. Genetic modifications or serial passages are used to reduce virulence while retaining immunogenicity. Example: BPZE1
- Other names
- Attenuated Bordetella pertussisLive attenuated B. pertussis vaccineBPZE1
02
Mechanism of action
The attenuated B. pertussis strain replicates within the host to a limited extent, expressing key antigens (FHA, PRN, FIMs) that stimulate the immune system, leading to the production of antibodies and cell-mediated immunity against wild-type B. pertussis.
03
Biological functions
Antigen presentationImmune system stimulationInduction of humoral immunityInduction of cellular immunity
04
Disease associations
Prevention of pertussis (whooping cough)
05
Safety considerations
Potential for reversion to virulence (though highly unlikely with genetically modified strains)Contraindicated in immunocompromised individualsContraindicated in pregnant womenPossible adverse reactions such as fever or mild respiratory symptoms
06
Biomarkers
Anti-pertussis antibody titers (e.g., anti-PT, anti-FHA, anti-PRN)B cell memory responseT cell memory response
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