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Target intelligence / Profile preview
Bordetella pertussis Antigen (Pertussis Toxin + Filamentous Hemagglutinin + Pertactin + Fimbriae Types 2 & 3)
- Molecular classification
- Toxin, Adhesin, Surface protein, Pili
01
Overview
A combination of key antigens from *Bordetella pertussis*, including pertussis toxin (PT), filamentous hemagglutinin (FHA), pertactin (PRN), and fimbriae types 2 and 3 (Fim2, Fim3). These antigens are used in acellular pertussis vaccines to induce protective immunity by stimulating antibody responses against multiple virulence factors.
- Other names
- Pertussis Toxin (PT)Filamentous Hemagglutinin (FHA)Pertactin (PRN)Fimbriae types 2 & 3 (Fim2, Fim3)Acellular pertussis vaccine antigens
02
Mechanism of action
Induction of neutralizing antibodies against pertussis toxin and blocking bacterial adherence via anti-FHA, anti-PRN, and anti-FIM antibodies.
03
Biological functions
AdhesionToxicityImmune response induction
04
Disease associations
Whooping cough/Pertussis
05
Safety considerations
Antigenic drift (PRN, PT)Vaccine efficacy variation due to strain differences
06
Interacting drugs
Adacel
8 more in the full profile.
07
Biomarkers
Anti-PT IgGAnti-FHA IgGAnti-PRN IgGAnti-Fim2/3 IgG
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