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Target intelligence / Profile preview
Bordetella pertussis Antigens (Acellular Components) (aP Antigens)
- Target
- aP Antigens
- Molecular classification
- Protein, Toxin, Adhesin, Surface Antigen
01
Overview
Acellular pertussis antigens are purified components of *Bordetella pertussis* used in modern aP vaccines. They include pertussis toxoid (PT), filamentous hemagglutinin (FHA), pertactin (PRN), and sometimes fimbriae types 2 and 3 (FIM2/3). These antigens elicit an immune response, generating antibodies that neutralize toxins or block bacterial colonization, thereby preventing or reducing the severity of whooping cough. They are safer than whole-cell vaccines.
- Other names
- Acellular Pertussis AntigensPertussis Toxoid (PT)Filamentous Hemagglutinin (FHA)Pertactin (PRN)Fimbriae Types 2 and 3 (FIM2/3)
02
Mechanism of action
Vaccine antigens stimulate antibody production, neutralizing toxins or blocking bacterial adherence.
03
Biological functions
AdhesionToxin ActivityImmune Response InductionColonization
04
Disease associations
InfectionWhooping CoughPertussis
05
Safety considerations
Local reactions at injection siteFeverHypersensitivity reactions (rare)
06
Interacting drugs
None (targets for vaccine development, not drug targets directly)
07
Biomarkers
IgG antibody levels against PT, FHA, PRN, and FIM2/3 (for vaccine efficacy)
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