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Target intelligence / Profile preview
Bordetella pertussis Antigens (Pertussis Toxin & Other Components) (N/A)
- Target
- N/A
- Molecular classification
- Exotoxin, Surface protein antigens, Protein
01
Overview
Bordetella pertussis antigens, primarily pertussis toxin (PT) and agglutinogens, are key virulence factors in whooping cough. PT is an AB5 exotoxin that disrupts immune cell function by ADP-ribosylating Gi proteins, leading to increased cAMP. Agglutinogens are surface proteins that induce antibody production and bacterial agglutination. These antigens are important vaccine components.
- Other names
- Pertussis ToxinAgglutinogensFimbriaeptxA/B/C/D/EBP3783Islet activating proteinNAD-dependent ADP-ribosyltransferase
02
Mechanism of action
Pertussis toxin ADP-ribosylates Gi alpha-subunit, leading to increased cAMP levels and disrupted immune cell function. Agglutinogens induce antibody-mediated agglutination.
03
Biological functions
ADP-ribosylationReceptor bindingImmune modulationInduction of antibody responseBacterial agglutination
04
Disease associations
Whooping coughPertussis infection
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