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Target intelligence / Profile preview
Bordetella pertussis antigens (Pertussis Toxoid and Filamentous Haemagglutinin) (PT and FHA)
- Target
- PT and FHA
- Molecular classification
- Protein exotoxin/toxoid, Surface adhesin, Antigen
01
Overview
Bordetella pertussis antigens, specifically pertussis toxoid (PT) and filamentous haemagglutinin (FHA), are key components of acellular pertussis vaccines. Pertussis toxoid is an inactivated form of pertussis toxin, disrupting host cell signaling. Filamentous haemagglutinin is a surface-associated protein adhesin, facilitating attachment to respiratory epithelial cells. Both antigens induce strong humoral immune responses, leading to the production of neutralizing and adhesion-blocking antibodies, providing protection against whooping cough.
- Other names
- Pertussis ToxoidFilamentous HaemagglutininPTFHA
02
Mechanism of action
Induction of neutralizing and adhesion-blocking antibodies
03
Biological functions
Host cell signaling disruption (Pertussis Toxoid)Bacterial adhesion (Filamentous Haemagglutinin)Immune response induction
04
Disease associations
Whooping cough (Bordetella pertussis infection)
05
Safety considerations
Hypersensitivity reactions to vaccine components
06
Interacting drugs
Adacel
8 more in the full profile.
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