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Bordetella pertussis Antigens (Whole Cell)
- Molecular classification
- Bacterial antigens, Inactivated bacteria, Vaccine component
01
Overview
Inactivated, entire Bordetella pertussis bacteria containing a full complement of bacterial antigens used to stimulate a broad immune response. Key components include pertussis toxin (PT), filamentous hemagglutinin (FHA), fimbriae (Fim), and pertactin (PRN).
- Other names
- Whole cell B. pertussis antigenswP antigensInactivated whole cell pertussis
02
Mechanism of action
Induction of humoral and cellular immunity against Bordetella pertussis through exposure to a wide array of bacterial antigens.
03
Biological functions
Antigen presentationImmune stimulationAntibody productionT-cell activation
04
Disease associations
Prevention of pertussis (whooping cough)Induction of immunity
05
Safety considerations
Reactogenicity (fever, local reactions)Potential for rare neurological complications
06
Biomarkers
Anti-B. pertussis antibody titers (e.g., anti-PT, anti-FHA)B. pertussis-specific T cell responses
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