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Target intelligence / Profile preview
Bordetella pertussis Fimbriae Types 2 & 3 (None)
- Target
- None
- Molecular classification
- Protein, Adhesin, Surface Antigen
01
Overview
Bordetella pertussis expresses two main serologically distinct fimbrial antigens, Fimbriae type 2 (Fim2) and Fimbriae type 3 (Fim3). These surface-exposed protein structures act as adhesins, facilitating attachment to respiratory epithelial cells. They are key components of acellular pertussis vaccines, inducing protective antibody responses. Biological differences between strains expressing different fimbria types can affect virulence characteristics such as biofilm formation and immune response induction.
- Other names
- Fimbriae type 2 (Fim2)Fimbriae type 3 (Fim3)FIM2FIM3Bordetella pertussis antigens
02
Mechanism of action
These are vaccine components that elicit an antibody response against Bordetella pertussis, preventing or mitigating infection.
03
Biological functions
Adhesion to respiratory epitheliumColonizationImmune modulationBiofilm formation
04
Disease associations
InfectionWhooping cough (Pertussis)
05
Safety considerations
Typical vaccine-related adverse events (e.g., injection site reactions, fever)Potential for strain variation and reduced vaccine efficacy over time
06
Interacting drugs
Adacel
4 more in the full profile.
07
Biomarkers
Anti-fimbrial antibodies (IgG, IgA)
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