Molecular Classification
Pilin, Adhesin, Surface Appendage
Other Names
FIM2, FIM3, Type 2 Fimbriae, Type 3 Fimbriae, B. pertussis Fimbriae
Disease Roles
Whooping cough (Pertussis)Infection

Bordetella pertussis Fimbriae Types 2 and 3 Overview

Fimbriae types 2 and 3 (FIM2/FIM3) are filamentous protein structures on the surface of Bordetella pertussis, essential for adhesion to host tissues, biofilm formation, and colonization. They are key virulence factors and components of some acellular pertussis vaccines. FIM2 and FIM3 differ in their production levels, biofilm formation capabilities, autoagglutination, survival in cord blood, and cytokine induction profiles. Genetic variations in the fimbrial loci contribute to serotype differences among circulating strains.

Mechanism of Action

Fimbriae are targeted by antibodies induced by vaccination, preventing adhesion to host cells and reducing colonization.

Biological Functions

Adhesion to host tissues
Biofilm formation
Immune modulation
Colonization

Disease Associations

Whooping cough (Pertussis)
Infection

Safety Considerations

No safety concerns listed

Interacting Drugs

Acellular Pertussis Vaccines