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Target intelligence / Profile preview
Bordetella pertussis Fimbriae Types 2 and 3 (FIM2/3)
- Target
- FIM2/3
- Molecular classification
- Proteinaceous pili, Adhesin, Antigen
01
Overview
Bordetella pertussis Fimbriae Types 2 and 3 (FIM2/3) are serologically distinct fimbrial antigens expressed on the surface of Bordetella pertussis. These pili mediate attachment to host respiratory epithelial cells, facilitating colonization and persistence. They are key components of acellular pertussis vaccines, inducing protective antibody responses that block bacterial adhesion. Fim2 and Fim3 are regulated by the BvgA/S system and poly(C) tract length in their promoter regions.
- Other names
- Bordetella pertussis fimbriae 2/3 antigen/vaccineFim2Fim3
02
Mechanism of action
Induction of neutralizing antibodies that block bacterial adhesion
03
Biological functions
Adhesion to respiratory epitheliumImmune responseColonizationHeparin binding
04
Disease associations
InfectionWhooping cough
05
Interacting drugs
Adacel
4 more in the full profile.
06
Biomarkers
Anti-Fim2 antibodiesAnti-Fim3 antibodies
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