Boron Neutron Capture Therapy (BNCT) via LAT1-mediated Boron-10 uptake (BNCT)

Boron Neutron Capture Therapy (BNCT) is a cancer treatment modality that utilizes the selective accumulation of the Boron-10 isotope (^{10}B) in tumor cells, mediated by the L-type amino acid transporter 1 (LAT1), followed by irradiation with low-energy thermal neutrons. The neutron capture reaction results in the emission of high-LET alpha particles and lithium nuclei, inducing localized DNA damage and cytotoxicity specifically within tumor cells while sparing surrounding healthy tissue.

Other names

Boron Neutron Capture TherapyBPA-mediated BNCTLAT1-targeted BNCT^{10}B Neutron Capture Therapy

Selective accumulation of Boron-10 in tumor cells via LAT1, followed by neutron irradiation that triggers local emission of alpha particles and lithium nuclei, resulting in highly localized ionizing radiation damage to cancer cells.