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Botrytis cinerea (major causal agent of bunch rot diseases in grapes)

Molecular classification
Other (Fungal plant pathogen; not classifiable as receptor, enzyme, transporter, or specific molecular entity)
01

Overview

**Botrytis cinerea** is the primary fungal pathogen causing bunch rot (gray mold) in grapes and many other crops, leading to significant losses in yield and quality worldwide[1][2][3][4][5]. It is a necrotrophic ascomycete, meaning it infects, kills, and consumes plant tissue, often entering through wounds or natural openings and spreading under cool, humid conditions commonly found prior to harvest[1][2][5][6]. Other fungi, including species of Aspergillus and Penicillium, may also contribute to grape bunch rot but are less prevalent than *B. cinerea*[3]. Disease management is complicated by the pathogen's ability to overwinter, its broad host range, genetic variability, and frequent development of fungicide resistance[1][4][5]. "Fungal pathogens causing bunch rot diseases" is a collective term and does not refer to a single molecular target, gene, or protein, but rather to a disease-causing guild of plant-associated fungi.

Other names
Grey mold (common disease name)Botrytis bunch rotBunch rot fungiGray moldBotryotinia fuckeliana (sexual/teleomorph stage)Fungal bunch rot pathogens
02

Mechanism of action

Inhibit fungal respiration (e.g., SDHI fungicides like boscalid) - Inhibit sterol biosynthesis (e.g., fenhexamid) - Disrupt signal transduction or protein synthesis (e.g., cyprodinil targets methionine biosynthesis) - Block spore germination or mycelial growth[1][4][5]

03

Biological functions

Plant pathogenesisNecrotrophy (killing and consuming host tissue)Conidiation (spore formation)Sclerotia formation (survival structure production)Wound colonizationSecondary metabolite production[1][2][5]
04

Disease associations

Infection (plant pathology; major grape and crop disease)Other (causes economic loss in agriculture; postharvest spoilage)[1][5]
05

Safety considerations

Fungicide resistance develops rapidly in B. cinerea, especially to single-site fungicides[1]Environmental and consumer concerns regarding fungicide residues and non-target effectsDifficulties in managing due to broad host range and environmental persistence[1][4][5]
06

Interacting drugs

Iprodione

7 more in the full profile.

07

Biomarkers

Botanical/phenotypic: Presence of sclerotia, conidiophores, and characteristic gray mold on plantsMolecular: Detection of *B. cinerea* DNA or specific metabolites in plant tissue[1][4]

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