Boule homolog, RNA binding protein (BOLL)

Boule homolog, RNA binding protein (BOLL) is a member of the DAZ gene family, which is required for germ cell development, specifically during spermatogenesis. The BOLL gene encodes an RNA-binding protein structurally more similar to Drosophila Boule than to other human DAZ family members. Loss of BOLL function leads to male infertility, primarily through a block at the meiotic G2/M transition, resulting in azoospermia (absence of sperm in semen). The protein may regulate the translation of specific mRNAs by binding their 3’-UTRs. Although BOLL has been associated with several malignancies in the literature, there is no evidence identifying it as a therapeutic target, nor are there approved drugs that interact directly with BOLL. Its primary clinical role lies in reproduction and fertility, with some research interest in cancer correlation

Other names

BOULEboule homologprotein boule-likeboule RNA binding proteinboule-likeBOLLboule-like RNA binding protein

Not applicable; no known drugs target this molecule.