Bradykinin Receptor B2 (BDKRB2)

Bradykinin receptor B2 is a G-protein coupled receptor (GPCR) that serves as the primary receptor for the peptide hormone bradykinin. It is encoded by the human gene BDKRB2 and is widely expressed in peripheral tissues, where it mediates many of bradykinin’s physiological effects. Upon binding to its ligands—bradykinin or kallidin—the BDKRB2 receptor undergoes conformational changes that activate associated G proteins, primarily Gq and Gi. The receptor also stimulates mitogen-activated protein kinase (MAPK) pathways. Polymorphisms in the BDKRB2 gene have been linked to variations in blood pressure profiles and microvascular function. The antagonist icatibant is clinically used for treating hereditary angioedema by blocking excessive bradykinin signaling through this receptor.

Other names

B2 receptorBK2 receptor

Blocks excessive bradykinin signaling.