Gosset Molecular Classification
Receptor Tyrosine Kinase
Other Names
TrkB, Tropomyosin receptor kinase B
Disease Roles
Brain-derived Neurotrophic Factor Receptor TrkB Overview
NTRK2, also known as TrkB (Tropomyosin receptor kinase B), is a membrane-bound receptor tyrosine kinase primarily involved in the development and function of the nervous system. It is activated by neurotrophins such as BDNF, NT-4, and NT-3, triggering downstream signaling cascades that promote neuronal survival, differentiation, synaptic plasticity, and axon/dendrite growth. Dysregulation of NTRK2 has been linked to obesity, mood disorders, and neurological diseases.
Mechanism of Action
Ligand binding induces receptor dimerization and autophosphorylation, activating downstream signaling pathways (Ras-MAPK/ERK, PI3K-Akt, PLCγ).
Biological Functions
Neuronal survival
Neuronal differentiation
Synaptic plasticity
Axon/dendrite growth
Cell proliferation
Signal transduction
Disease Associations
Obesity
Mood disorders
Depression
Neurological diseases
Neurodevelopmental conditions
Safety Considerations
No safety concerns listed