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Target intelligence / Profile preview
Bromodomain and Extraterminal Domain (BET) Proteins (BET)
- Target
- BET
- Molecular classification
- Epigenetic regulator, Transcription factor, Bromodomain-containing protein
01
Overview
The Bromodomain and Extraterminal domain protein family comprises highly conserved nuclear regulators that interpret histone acetylation marks via tandem bromodomains while using their ET domains for diverse protein-protein interactions crucial for controlling gene expression programs across health and disease contexts. They play a central role in gene transcription, chromatin remodeling, and cellular processes such as proliferation, differentiation, and response to viral infection.
- Other names
- BRD2BRD3BRD4BRDT
02
Mechanism of action
Inhibition of bromodomain-acetyllysine interactions
03
Biological functions
Gene transcriptionChromatin remodelingCell cycle progressionCellular proliferationCellular differentiationRegulation of gene expressionRecruitment of co-factors
04
Disease associations
OncogenesisCancerViral latencyViral infectionInflammatory diseases
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