Bromodomain-containing proteins (BCPs)

Bromodomain-containing proteins Overview

Bromodomain-containing proteins are essential epigenetic regulators that read histone acetylation marks via a conserved structural module (~110 aa). They orchestrate gene expression programs through recruitment/scaffolding functions within large multiprotein complexes involved in transcriptional control and chromatin dynamics. Their dysregulation is linked to numerous diseases—including cancers—and they represent promising therapeutic targets due to their druggability by small-molecule inhibitors targeting the conserved binding pocket within the bromodomain itself.

Mechanism of Action

Inhibition of bromodomain binding to acetylated lysine residues

Biological Functions

Safety Considerations

Interacting Drugs