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Target intelligence / Profile preview
C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)
- Target
- MTHFD1
- Molecular classification
- Enzyme, Multifunctional enzyme
01
Overview
MTHFD1 encodes a trifunctional enzyme that catalyzes sequential reactions in the interconversion of one-carbon derivatives of tetrahydrofolate. These reactions are essential for methionine synthesis, thymidylate synthesis, and de novo purine biosynthesis. Mutations in MTHFD1 can cause methylenetetrahydrofolate dehydrogenase 1 deficiency, leading to immune dysfunction and anemia.
- Other names
- C1-THF synthaseMethylenetetrahydrofolate dehydrogenase/Cyclohydrolase 1MTHFCMTHFDMethenyltetrahydrofolate cyclohydrolaseFormyltetrahydrofolate synthetase
02
Biological functions
Methionine synthesisThymidylate synthesisDe novo purine biosynthesisFolate-dependent one-carbon metabolism
03
Disease associations
Methylenetetrahydrofolate dehydrogenase 1 deficiencyCombined immunodeficiency and megaloblastic anemia with or without hyperhomocysteinemia (CIMAH)Immune dysfunctionAnemia
04
Safety considerations
Potential for disrupting nucleotide and amino acid biosynthesisRare inherited disorders affecting immunity and red blood cell formation
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