C-fiber Afferent Neuron (C-fiber)

C-fiber Afferent Neuron Overview

C-fiber afferent neurons are a class of unmyelinated sensory nerve fibers that transmit information from the periphery to the central nervous system. They are primarily responsible for conveying slow, diffuse, and lingering sensations such as burning pain, temperature (warmth), itch, and certain types of touch. Activation leads to sensations associated with chronic pain conditions due to their role in persistent/burning pain. In airways/lungs ("bronchopulmonary" C-fibers): Mediate cough reflexes; modulate breathing patterns; contribute to airway constriction/inflammation responses during disease states like asthma or infection.

Mechanism of Action

Biological Functions

Safety Considerations