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Target intelligence / Profile preview
C-Raf Kinase (c-Raf)
- Target
- c-Raf
- Molecular classification
- Serine/threonine kinase, Enzyme, Protein kinase
01
Overview
C-Raf kinase, also known as Raf-1, is a serine/threonine protein kinase encoded by the RAF1 gene in humans. The mRNA for C-Raf encodes a multidomain protein that plays a central role in the MAPK/ERK signaling pathway, which regulates cell proliferation, differentiation, survival, and migration. Its activation leads to phosphorylation of MEK1/2 kinases, which then activate ERK kinases—key regulators of cell fate decisions such as proliferation or differentiation. Upregulation or mutation of RAF1/c-Raf is implicated in various cancers including triple-negative breast cancer.
- Other names
- Raf-1RAF1
02
Mechanism of action
Inhibition of C-Raf kinase activity
03
Biological functions
Signal transductionCell proliferationCell differentiationCell survivalCell migrationApoptosisCell motilityWound healingT-cell developmentB-cell development
04
Disease associations
CancerProliferative disorders
05
Safety considerations
Aberrant activation contributing to uncontrolled cellular proliferationPotential for off-target effects due to kinase family similarities
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