C-type lectin domain family 6 member A protein (Dectin-2)

C-type lectin domain family 6 member A protein, commonly known as Dectin‑2, is a type II transmembrane receptor belonging to the C-type lectin-like receptor family. It is primarily expressed on macrophages and dendritic cells, with lower expression in Langerhans cells and peripheral blood monocytes that can increase during inflammation. Dectin‑2 functions as a pattern recognition receptor by specifically binding α-mannans—carbohydrate structures found on the surface of many fungi—and other high mannose-containing molecules. Upon ligand binding, it initiates intracellular signaling through the CARD9-Bcl10-Malt1 pathway leading to cytokine production and activation of innate immune responses against fungal pathogens. Additionally, Dectin‑2 has been implicated in modulating allergic responses by recognizing allergens such as house dust mite components and promoting inflammatory mediator release essential for Th2-driven airway inflammation. Diseases associated with dysfunction or altered expression include various fungal infections and potentially inflammatory or allergic conditions[1][5][7].

Other names

CLEC6ACLEC4NCLECSF10Dectin-2C-type lectin domain containing 6AhDECTIN-2