C-X-C chemokine receptor 1; C-X-C chemokine receptor 2 (CXCR1 (for C-X-C chemokine receptor 1); CXCR2 (for C-X-C chemokine receptor 2))

CXCR1 and CXCR2 are **class A G protein-coupled receptors** located on the plasma membrane of leukocytes and other cell types. They bind ELR+ CXC chemokines (primarily CXCL8/IL-8 for CXCR1 and CXCL1, CXCL2, CXCL3, CXCL5, CXCL6, CXCL7, CXCL8 for CXCR2)[1][2]. These receptors transduce signals that recruit and activate neutrophils during infection and inflammation, and also play roles in endothelial cell function, angiogenesis, and tumorigenesis. CXCR1 has a preference for monomeric chemokines, while CXCR2 binds both monomeric and dimeric forms, reflecting differences in their structure and ligand interaction[5]. Both receptors are highly conserved in vertebrates and are localized adjacent on chromosome 2q34-q35[1]. Their targeting has therapeutic promise in cancer, chronic inflammation, and infection, but also poses safety risks due to interference with host defense mechanisms[2][6].

Other names

IL-8 receptor Ainterleukin-8 receptor AIL8RACD181IL-8 receptor Binterleukin-8 receptor BIL8RBCD182IL-8 receptorsELR+ chemokine receptors

Inhibition of chemokine-induced neutrophil recruitment\nBlockade of GPCR-mediated signaling cascades (e.g., Ras/MAPK, PI3K/Akt, PLC/PKC)\nSuppression of inflammation and ROS generation by impeding CXCL8/CXCL1/CXCL2 signaling through receptor antagonism[2][4][6]