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C-X-C motif chemokine receptor 4 (CXCR4) (CXCR4)

Target: CXCR4

Overview

C-X-C motif chemokine receptor 4 (CXCR4) is a Class A G protein-coupled receptor that serves as the primary receptor for the chemokine CXCL12, also known as stromal cell-derived factor-1 (SDF-1) [1, 18]. This signaling axis is fundamental to physiological processes such as hematopoiesis, immune cell trafficking, and embryonic development, particularly in the heart and central nervous system [11, 12]. In the context of disease, CXCR4 is a critical co-receptor for the entry of T-tropic HIV-1 into CD4+ T cells and}

Other names: SDF-1 receptor [2]CD184 [2, 3]Fusin [2, 3]LESTR [2, 3]NPY3R [2, 15]WHIM [2, 15]

Biological functions

Chemotaxis [1, 2, 10]Cell migration [1, 4, 8]Hematopoiesis [1, 3, 11]Immune response [1, 12]Organogenesis [1, 11]Vascularization [3, 11]B-cell development [7]

Biomarkers

CXCR4 expression (IHC) [24]CXCR4 surface expression (Flow cytometry) [22]68Ga-Pentixafor PET/CT uptake [23]CXCL12 serum levels [16]

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