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Target intelligence / Profile preview
Ca(V)3.2 T-type Calcium Channel (CaV3.2)
- Target
- CaV3.2
- Molecular classification
- Voltage-gated calcium channel, Ion channel, T-type calcium channel, LVA calcium channel
01
Overview
The Ca(V)3.2 T-type calcium channel is a voltage-gated calcium channel that plays a critical role in neuronal excitability, pain signaling, cardiac pacemaking, and other physiological processes. It is primarily expressed in small-to-medium diameter DRG neurons, thalamic relay neurons, and heart sinoatrial node cells. Ca(V)3.2 mediates calcium influx upon membrane depolarization at relatively negative potentials, contributing to repetitive firing and rhythmic activity. It is implicated in chronic pain conditions and bladder pain syndrome, making it a therapeutic target for these disorders.
- Other names
- CACNA1HT-type calcium channel alpha 1H subunitLow-voltage-activated calcium channelCav3.2[7][8]
02
Mechanism of action
Blockage of calcium ion influx through Ca(V)3.2 channels
03
Biological functions
Calcium ion influxNeuronal excitabilityAction potential generationRhythmic firingPacemakingPain signalingRegulation of afferent nerve response
04
Disease associations
Chronic painNeuropathic painInterstitial cystitisBladder pain syndromeCardiac arrhythmias
05
Safety considerations
Potential cardiac effects due to expression in heartOff-target effects on other calcium channels
06
Interacting drugs
TTA-A2
5 more in the full profile.
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