Cactin, spliceosome C complex subunit (CACTIN)

Cactin, encoded by the CACTIN gene, is a spliceosome C complex subunit involved in the facilitation of pre-mRNA splicing, including the excision of specific introns and the regulation of splicing for important cell cycle genes such as CDCA5 (Sororin)[1][2]. Cactin plays a regulatory role in the innate immune system as a negative regulator of several pro-inflammatory pathways, including those mediated by Toll-like receptors, interferon regulatory factors (IRFs), and the canonical NF-κB signaling pathway[1][2][5]. This protein is localized in the cytosol and nuclear speckles of cells, with highest expression observed in testis and spleen, and is conserved across vertebrates, plants, and fungi[1][2]. Originally identified as a renal carcinoma antigen, cactin has been primarily studied for its roles in RNA binding, immune modulation, and was first described in Drosophila[1][2][5]. There are currently no drugs, established biomarkers, or specific safety concerns directly associated with cactin as a therapeutic target, and it is not considered a classical drug target such as a receptor, enzyme, or transporter[1].

Other names

Splicing factor CactinC19orf29NY-REN-24fSAPcRenal carcinoma antigen NY-REN-24NY REN 24 antigenFunctional spliceosome-associated protein cCactin homolog (Drosophila)