Cadherin-3 messenger RNA 3' untranslated region (CDH3 mRNA 3'UTR) (CDH3 mRNA 3'UTR)

The Cadherin-3 messenger RNA 3' untranslated region (CDH3 mRNA 3'UTR) is a critical regulatory segment of the transcript encoding P-cadherin, a calcium-dependent cell-cell adhesion molecule (NCBI Gene: 1001). This region serves as a primary site for post-transcriptional control, containing multiple binding motifs for microRNAs (miRNAs) such as the miR-200 family and miR-145, which modulate mRNA stability and translation (PubMed: 21475224, 25633145). In various epithelial cancers, including triple-negative breast cancer and pancreatic cancer, the loss of miRNA-mediated repression at this 3'UTR leads to the pathological overexpression of P-cadherin, which promotes epithelial-mesenchymal transition (EMT), cell migration, and metastasis (PubMed: 24573133). While coding mutations in the CDH3 gene are associated with rare genetic conditions like hypotrichosis with juvenile macular dystrophy, the 3'UTR is increasingly recognized as a therapeutic target for RNA-based interventions (UniProt: P22223). Current research explores the use of miRNA mimics and antisense oligonucleotides (ASOs) to bind this region and restore normal regulatory control or silence the oncogenic transcript. Although clinical-stage drugs currently focus on the P-cadherin protein, the CDH3 mRNA 3'UTR represents a high-specificity target for precision RNA therapeutics.

Other names

P-cadherin mRNA 3'UTRCDH3 3'-untranslated regionCDH3 3'UTRCadherin-3 3'UTR

miRNA-mediated gene silencing, RNA interference, and antisense-mediated mRNA degradation.