Gosset Molecular Classification
Type II classical cadherin, Transmembrane glycoprotein
Other Names
CDH6 protein, K-cadherin
Disease Roles
Cadherin-6 Overview
Cadherin-6 (CDH6) is a calcium-dependent cell adhesion protein that belongs to the cadherin superfamily. It mediates homophilic cell-cell adhesion and plays critical roles in tissue morphogenesis and differentiation, particularly in the kidney where it inhibits tubulogenesis. Dysregulation of CDH6 has been linked to diseases such as cancer and craniofacial-deafness-hand syndrome.
Mechanism of Action
Biological Functions
Cell-cell adhesion
Regulation of tubulogenesis
Cell migration
Cell junction organization
Disease Associations
Cancer
Craniofacial-deafness-hand syndrome
Renal cell carcinoma
Safety Considerations
- Dysregulation associated with tumor growth and metastasis