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Target intelligence / Profile preview
Cadmium Ion (Cd²⁺)
- Target
- Cd²⁺
- Molecular classification
- Inorganic Ion, Metal Ion
01
Overview
The cadmium ion (Cd²⁺) is the divalent cation form of cadmium, a highly toxic heavy metal. It has no known physiological function and exerts its toxicity through various mechanisms, including disruption of calcium homeostasis, enzyme inhibition, induction of oxidative stress, and mitochondrial dysfunction. Exposure to cadmium ions can lead to a range of adverse health effects, including kidney disease, bone damage, cancer, and neurotoxicity. Chelation therapy is used to remove cadmium from the body in cases of acute or chronic exposure.
- Other names
- Cadmium(2+)Cd(II)Divalent Cadmium
02
Mechanism of action
Chelating agents bind to cadmium ions, facilitating their excretion from the body. Other drugs target specific cadmium-induced toxicities.
03
Biological functions
Enzyme InhibitionProtein MisfoldingDisruption of Calcium HomeostasisOxidative Stress InductionMitochondrial Dysfunction
04
Disease associations
CancerOsteoporosisKidney DiseaseNeurotoxicityCardiovascular DiseaseReproductive ToxicityItai-Itai disease
05
Safety considerations
NephrotoxicityCarcinogenicitySkeletal DamageDevelopmental Toxicity
06
Interacting drugs
Chelating Agents (e.g., EDTA, DMSA, DMPS)
2 more in the full profile.
07
Biomarkers
Cadmium levels in bloodCadmium levels in urineMetallothionein levels
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