Calcitonin Receptor (with RAMPs) (CTR (with RAMPs))

The calcitonin receptor (CTR) is a class B G protein-coupled receptor that primarily binds the peptide hormone calcitonin, which plays a key role in calcium homeostasis by inhibiting osteoclast activity. The pharmacology and function of the CTR are significantly modulated by its interaction with receptor activity-modifying proteins (RAMPs). Different RAMP isoforms (RAMP1, RAMP2, RAMP3) alter ligand selectivity, allowing the CTR to respond to a variety of ligands, including calcitonin, amylin, CGRP variants, and adrenomedullins. This modularity generates distinct receptors with unique pharmacological profiles for members of the calcitonin peptide family. The CTR plays a role in bone metabolism, glycemic control, and potentially migraine pathophysiology. High-affinity forms like salmon calcitonin are used clinically to treat conditions such as hypercalcemia, Paget’s disease, and osteoporosis.

Other names

Calcitonin ReceptorCTRAMY_1(a) receptor (hCT(a)-RAMP1)Calcitonin Receptor/Receptor Activity-Modifying Protein Complex

Calcitonin binds to the calcitonin receptor, inhibiting osteoclast activity and reducing bone resorption. RAMPs modulate ligand binding affinity and receptor trafficking.