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Target intelligence / Profile preview
Calcium-Activated Potassium Channel (Large Conductance) (BK)
- Target
- BK
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel, Calcium-activated ion channel
01
Overview
The large-conductance, calcium-activated potassium channel (BK channel) is a voltage- and calcium-sensitive potassium channel. It regulates membrane potential by facilitating K+ efflux when activated by increases in intracellular Ca2+ and/or membrane depolarization. The functional channel is a tetramer of alpha subunits encoded by the KCNMA1 gene, with regulatory beta subunits that modulate activity. It plays roles in action potential repolarization, neuronal excitability, neurotransmitter release, hormone secretion, smooth muscle tone, and other processes. It is a therapeutic target for hypertension, asthma, COPD, and neurological disorders.
- Other names
- BK channelBK(Ca)Slo1MaxiKKCa1.1
02
Mechanism of action
Modulation of potassium ion flux across the cell membrane
03
Biological functions
Membrane potential regulationAction potential repolarizationNeuronal excitability controlNeurotransmitter releaseHormone secretionSmooth muscle tone modulationCochlear hair cell tuningApoptosis signalingCardioprotection
04
Disease associations
HypertensionAsthmaCOPDNeurological disorders
05
Safety considerations
Complex tissue-specific effectsPotential for off-target effects due to widespread expression
06
Interacting drugs
BK channel activators
1 more in the full profile.
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