Calcium-activated potassium channel subunit alpha-1 (SLO-1) (SLO-1)

The nematode SLO-1 calcium-activated potassium channel is a large-conductance (BK) ion channel that plays a critical role in modulating neuromuscular activity (Guest et al., 2007, PMID: 17947313). It is primarily expressed in the neurons and muscles of nematodes, where it regulates the release of neurotransmitters and controls muscle contraction (Crisford et al., 2011, PMID: 21435179). The channel opens in response to increases in intracellular calcium concentrations and membrane depolarization, facilitating potassium efflux and subsequent membrane hyperpolarization (Welz et al., 2011, PMID: 21245134). This physiological process is vital for the coordination of locomotion, feeding, and egg-laying in worms like Caenorhabditis elegans and various parasitic species (UniProt, P41929). SLO-1 is the principal molecular target for the anthelmintic drug emodepside, which binds to the channel and acts as a potent activator (Guest et al., 2007). Drug-induced activation of SLO-1 causes persistent hyperpolarization, leading to flaccid paralysis of the nematode's pharyngeal and body wall muscles (Crisford et al., 2011). This paralysis prevents the parasite from feeding and maintaining its position within the host, eventually resulting in its death. While SLO-1 has a human ortholog known as KCNMA1, emodepside shows high selectivity for the nematode version, making it a valuable therapeutic target with minimal host toxicity (Welz et al., 2011).

Other names

BK channelSlowpoke-1Large-conductance calcium-activated potassium channelslo-1KCNMA1 nematode ortholog

Agonist/Activator