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Calcium Adenosine Triphosphatase (Plasmodium) (PfATP6)
- Target
- PfATP6
- Molecular classification
- Enzyme, P-type ATPase, Calcium Transporter
01
Overview
Calcium adenosine triphosphatase in *Plasmodium*, specifically PfATP6 in *Plasmodium falciparum*, is a P-type ATPase enzyme responsible for transporting calcium ions (Ca²⁺) across cellular membranes. It regulates cytosolic Ca²⁺ levels by pumping calcium from the cytoplasm into the ER lumen, which is essential for parasite development, fertilization, and cell signaling. PfATP6 is a validated target for antimalarial drugs like artemisinins. Mutations such as S769N and L263E can alter drug sensitivity but may also incur fitness costs.
- Other names
- PfSERCAPfATPase6
02
Mechanism of action
Inhibition of PfATP6 activity, disrupting calcium homeostasis.
03
Biological functions
Calcium transportRegulation of cytosolic calcium levelsAsexual blood stage developmentGametocyte maturation and fertilizationMotility and invasion processesCalcium signaling
04
Disease associations
InfectionMalaria
05
Safety considerations
Potential for off-target effects on human SERCA enzymes, although minimized by structural divergence and selective inhibition.Development of resistance mutations.
06
Interacting drugs
Artemisinins
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