Calcium binding protein 39-like mRNA 3'-untranslated region (CAB39L mRNA 3'-UTR)

The Calcium binding protein 39-like (CAB39L) mRNA 3'-untranslated region (3'-UTR) is a critical regulatory segment of the CAB39L transcript that governs the expression of the CAB39L protein, also known as MO25-beta (UniProt: Q9H9S4). CAB39L serves as a vital scaffold component of the LKB1-STRAD-CAB39L heterotrimeric complex, which is necessary for the full activation of Liver Kinase B1 (LKB1), a master upstream kinase of the AMP-activated protein kinase (AMPK) family (NCBI Gene: 27279). The 3'-UTR of CAB39L contains multiple seed sequences for microRNAs, such as miR-107 and miR-497, which negatively regulate its expression through translational inhibition or mRNA decay (PubMed: 25670101). In various malignancies, including gastric cancer and nasopharyngeal carcinoma, the downregulation of CAB39L via its 3'-UTR is associated with increased cell proliferation, migration, and resistance to apoptosis (PubMed: 29130515). Consequently, the CAB39L mRNA 3'-UTR is an emerging focal point for RNA-based therapeutic interventions designed to modulate the LKB1/AMPK signaling axis in cancer and metabolic diseases. Experimental strategies targeting this region include miRNA mimics to suppress oncogenic signaling or antisense oligonucleotides to stabilize the transcript in tumor-suppressive contexts.

Other names

MO25L mRNA 3'-UTRMO25-beta mRNA 3'-UTRCalcium binding protein 39-like 3'-UTRCAB39L 3'-UTR

MicroRNA-mediated gene silencing or antisense-mediated modulation of mRNA stability and translation to regulate CAB39L protein levels.