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Target intelligence / Profile preview
Calcium Channel Protein (Nonspecific) (CaCh (Nonspecific))
- Target
- CaCh (Nonspecific)
- Molecular classification
- Ion Channel, Voltage-gated calcium channel (VGCC), Ligand-gated ion channel, Receptor-operated calcium channel, Store-operated calcium channel, TRP Channel, P2X receptor, Cyclic nucleotide-gated (CNG) channel, Acid-sensing ion channel, CatSper channel
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Overview
Calcium channel proteins are membrane-spanning ion channels that facilitate the selective or semi-selective passage of calcium ions (Ca²⁺) across cellular membranes. These channels play a critical role in numerous physiological processes, including muscle contraction, neurotransmitter release, gene expression, and cell signaling. The term "nonspecific" refers to cation channels that are permeable to calcium as well as other cations such as sodium and potassium. Key examples include voltage-gated calcium channels (VGCCs), ligand-gated channels, store-operated channels, Transient Receptor Potential (TRP) channels, P2X receptors, cyclic nucleotide-gated (CNG) channels, acid-sensing ion channels, and CatSper channels. Dysfunction or genetic mutations affecting these proteins have been linked to various diseases.
- Other names
- Nonselective Calcium ChannelCalcium-permeable cation channelCation Channel Permeable to Calcium
02
Mechanism of action
Channel blocker, Channel activator, Channel modulator
03
Biological functions
Muscle contractionNeurotransmitter releaseGene expressionCell signalingAction potential initiationNeuronal firing modulationSecretionExcitation-contraction couplingRegulation of gene transcription
04
Disease associations
Cardiac arrhythmiaEpilepsyNeurodegenerative disorderHypertensionImmune dysfunctionFamilial focal segmental glomerulosclerosisCancerInflammation
05
Safety considerations
Cardiac effectsNeurological effectsImmune suppression
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