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Target intelligence / Profile preview
Calcium Channel Protein (Vascular Smooth Muscle) (VSM Ca Channel)
- Target
- VSM Ca Channel
- Molecular classification
- Ion channel, Voltage-gated calcium channel
01
Overview
Calcium channel proteins in vascular smooth muscle (VSM) are integral membrane proteins that mediate the influx of calcium ions (Ca^{2+}) into smooth muscle cells. This calcium entry is essential for initiating and maintaining contraction, regulating vascular tone, and ultimately influencing systemic blood pressure. The most prominent type in VSM is the L-type voltage-gated calcium channel, specifically the CaV1.2 subtype.
- Other names
- Voltage-gated calcium channel (vascular smooth muscle)CaV1.2 Channel (Vascular Smooth Muscle)L-type Calcium Channel (Vascular Smooth Muscle)
02
Mechanism of action
Inhibition of calcium influx through L-type calcium channels, leading to vasodilation and reduced blood pressure
03
Biological functions
Excitation-contraction couplingRegulation of vascular toneCalcium signalingMembrane depolarization
04
Disease associations
HypertensionDiabetesCardiovascular disease
05
Safety considerations
HypotensionBradycardiaPeripheral edema
06
Interacting drugs
Calcium channel blockers (CCBs)
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