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Calcium channel protein subunit alpha1G (T-type) (CaV3.1)
- Target
- CaV3.1
- Molecular classification
- Ion channel, Voltage-gated calcium channel, T-type calcium channel
01
Overview
The alpha1G subunit (CaV3.1) is the pore-forming component of T-type voltage-gated calcium channels. These channels are characterized by low-voltage activation thresholds and transient currents due to rapid inactivation. They play critical roles in pacemaking activity in the heart, thalamic relay, and generating rhythmic burst firing patterns. Dysfunction of CACNA1G has been implicated in absence epilepsy, sleep disorders, pain syndromes, Parkinson’s disease, some cancers, and endocrine disorders. It is a primary pharmacological target for anti-seizure drugs used to treat absence epilepsy, such as ethosuximide.
- Other names
- CACNA1GCalcium channel, voltage-dependent, T type, alpha 1G subunit
02
Mechanism of action
Inhibition of T-type calcium channels, blocking burst mode activation.
03
Biological functions
Pacemaking activityNeuronal excitabilityThalamic relayBurst firingCalcium signaling
04
Disease associations
Absence epilepsySleep disordersPain syndromesParkinson’s diseaseCancerEndocrine disorders
05
Interacting drugs
Ethosuximide
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