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Target intelligence / Profile preview
Calcium-dependent Potassium Channel Subunit Alpha (BK Channel)
- Target
- BK Channel
- Molecular classification
- Ion channel, Potassium channel, Calcium-activated channel
01
Overview
The BK channel, also known as the calcium-dependent potassium channel alpha subunit, is a large conductance potassium channel activated by both membrane depolarization and increases in intracellular calcium or magnesium levels. It is a homotetramer composed of four identical alpha subunits encoded by the *KCNMA1* gene. BK channels are widely expressed throughout the body and have distinct roles depending on cell type. Mutations in *KCNMA1* are associated with several neurological disorders.
- Other names
- Big Potassium channelMaxi-K channelMaxi K ChannelSlo1SLO1hSlomSLOHSLOKCa1.1KCNMA1Stretch-Activated Kca ChannelSAKCABKTMBKCA Alpha Subunit
02
Mechanism of action
Channel blocker
03
Biological functions
Membrane repolarizationRegulation of neurotransmitter releaseRegulation of neuronal excitabilitySmooth muscle contraction controlPotassium secretion regulationHearing processesCell division and migration
04
Disease associations
Paroxysmal Nonkinesigenic Dyskinesia type 3Idiopathic Generalized Epilepsy type 16Liang-Wang syndrome
05
Interacting drugs
Charybdotoxin
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