Molecular Classification
Biochemical pathway, Cofactor
Disease Roles
Bleeding diathesesThrombosis

Calcium Ion-Mediated Coagulation Cascade Overview

The calcium ion-mediated coagulation cascade refers to the series of tightly regulated biochemical reactions in which calcium ions (Ca^{2+}) play a central role in enabling blood clot formation (hemostasis). Calcium ions are essential cofactors at multiple steps throughout the intrinsic, extrinsic, and common pathways of the coagulation cascade. Calcium ions facilitate binding between activated clotting factors and phospholipid surfaces on platelets. This is crucial for assembling enzyme complexes such as tenase (factors IXa/VIIIa) and prothrombinase (factors Xa/Va), which drive thrombin generation.

Mechanism of Action

Biological Functions

Blood clot formation
Hemostasis
Enzyme complex assembly

Disease Associations

Bleeding diatheses
Thrombosis

Safety Considerations

  • Impaired blood clotting due to chelation or deficiency of calcium.

Interacting Drugs

EDTA