Molecular Classification
Coagulation cascade, Signal transduction pathway
Disease Roles
ThrombosisBleeding disorders

Calcium-Mediated Coagulation Pathway Overview

The calcium-mediated coagulation pathway refers to the essential role of calcium ions (Ca²⁺) in the blood coagulation cascade, a complex process that leads to the formation of a blood clot (thrombus) to stop bleeding following vascular injury. Calcium acts as a critical cofactor at multiple steps in both intrinsic and extrinsic pathways of coagulation, facilitating interactions between clotting factors and cellular surfaces.

Mechanism of Action

Calcium acts as a cofactor facilitating the assembly and function of coagulation complexes (tenase and prothrombinase). Chelating agents sequester free calcium.

Biological Functions

Hemostasis
Blood coagulation
Platelet aggregation
Enzyme activation

Disease Associations

Thrombosis
Bleeding disorders

Safety Considerations

  • Hypocalcemia impairs hemostasis
  • Hypercalcemia may contribute to thrombosis

Interacting Drugs

EDTA
Vitamin K antagonists (e.g., Warfarin)
Direct oral anticoagulants (DOACs)