Molecular Classification
Enzyme, P-type ATPase, Ion transporter, Membrane protein
Other Names
Calcium pump, PMCA, SERCA, SPCA
Disease Roles
HypertensionHeart failureNeurodegenerative disease

Calcium Transporting ATPase Overview

Calcium transporting ATPases are a family of P-type primary ion transport ATPases responsible for moving calcium ions (Ca²⁺) across cellular membranes using energy derived from ATP hydrolysis. These enzymes play a critical role in maintaining low cytosolic Ca²⁺ concentrations, which is essential for proper cell signaling, muscle contraction-relaxation cycles, and overall cellular homeostasis. Main types include Plasma membrane Ca²⁺-ATPase (PMCA), Sarcoplasmic/endoplasmic reticulum Ca²⁺-ATPase (SERCA) and Secretory pathway Ca²⁺-ATPase (SPCA).

Mechanism of Action

ATP hydrolysis-driven calcium transport

Biological Functions

Calcium transport
Muscle contraction/relaxation
Cell signaling regulation
Maintenance of intracellular calcium homeostasis
Neurotransmitter release regulation
Apoptosis regulation

Disease Associations

Hypertension
Heart failure
Neurodegenerative disease
Muscular disorders
Excitotoxicity
Age-related degeneration

Safety Considerations

No safety concerns listed