Calpain-2 Catalytic Subunit (CAPN2)

The calpain-2 catalytic subunit is a calcium-dependent cysteine protease that plays a role in various cellular processes, including cytoskeletal remodeling, signal transduction, and apoptosis. It is implicated in several diseases, including cardiac disease, hepatic fibrosis, and neurodegenerative disorders. The enzyme is activated by calcium binding and undergoes autolytic processing, and its activity is regulated by the endogenous inhibitor calpastatin. Targeting CAPN2 may present therapeutic challenges due to its broad substrate specificity and essential physiological functions.

Other names

m-calpainmilli-calpain

Calpain-2 is a calcium-dependent cysteine protease involved in limited proteolysis of various substrates. Drugs targeting this molecule typically aim to inhibit its proteolytic activity, preventing its involvement in disease-related pathways.