Calsyntenin-3 (Clstn3) (Clstn3)

Mouse Calsyntenin-3 (Clstn3) pre-mRNA is the primary transcript of the Clstn3 gene, which encodes a type I transmembrane protein belonging to the cadherin superfamily (UniProt Consortium, 2023). In the central nervous system, Clstn3 is localized to postsynaptic membranes and plays a critical role in the development and maintenance of both excitatory and inhibitory synapses by interacting with presynaptic neurexins (Pettem et al., 2013). Beyond its neurological functions, Clstn3 and its isoforms, such as Clstn3β, have been identified as vital regulators of thermogenesis in brown and beige adipose tissue (Zeng et al., 2022). In these tissues, the protein product facilitates the functional organization of the thermogenic machinery, making it a key player in energy expenditure (Zeng et al., 2022). As a pre-mRNA, it serves as a substrate for complex splicing events that determine the ratio of functional protein isoforms, making it a potential target for antisense oligonucleotides (ASOs) designed to modulate metabolism or treat neurodegenerative conditions like Alzheimer's disease (Zeng et al., 2022; Pettem et al., 2013). Research into targeting Clstn3 pre-mRNA focuses on its role in synaptic plasticity and its emerging importance in metabolic health (NCBI Gene, 2024). While no clinical drugs currently target this molecule, it remains a significant subject of investigation for RNA-based therapeutic strategies (Zeng et al., 2022).

Other names

Alcadein-betaCSTN3Calsyntenin-3 pre-mRNAAlcadein-βMouse Clstn3 pre-mRNA

Antisense oligonucleotide-mediated splicing modulation or RNA interference (experimental)