Target intelligence / Profile preview

Phosphodiesterase 10A (PDE10A)

Target: PDE10A
Molecular classification: Enzyme, Cyclic nucleotide phosphodiesterase

Overview

Phosphodiesterase 10A (PDE10A) is an enzyme that degrades both cAMP and cGMP, key regulators of numerous physiological processes. It is highly enriched in the striatum and its inhibition offers therapeutic potential across neurological disorders, cardiovascular diseases, inflammatory conditions, and potentially certain cancers by modulating cell signaling pathways.

Other names: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10ATestis-specific phosphodiesterase PDE10A2

Mechanism of action

Selective inhibition of PDE10A, leading to increased levels of cAMP and cGMP in specific tissues such as the striatum.

Biological functions

Signal transductionRegulation of intracellular cAMP levelsRegulation of intracellular cGMP levelsModulation of neurotransmissionModulation of cardiac functionModulation of immune responseModulation of cell proliferation

Disease associations

SchizophreniaNeurological DisordersCardiovascular DiseaseHeart FailureInflammationAcute Lung InjuryCancerEpithelial Ovarian Cancer

Safety considerations

Potential for off-target effects due to non-selective inhibitors.Long-term effects of PDE10A inhibition on neurological function are not fully understood.

Interacting drugs

AMG-579

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