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Cancer Cell (Direct Lysis)
- Molecular classification
- Cellular Process
01
Overview
The term "Cancer cell (direct lysis)" refers to the process by which immune effector cells—primarily cytotoxic T lymphocytes (CTLs) and natural killer (NK) cells—directly induce the death of cancer cells through lytic mechanisms. This involves granule-mediated cytotoxicity (perforin/granzyme) and death receptor-mediated cytotoxicity (FasL/FasR, TRAIL/TRAIL-R). It is a fundamental aspect of immune surveillance and immunotherapy, where the goal is to eliminate malignant cells via direct cytotoxicity.
- Other names
- Tumor Cell LysisDirect Cytotoxicity of Cancer CellsCancer Cell Killing
02
Mechanism of action
Direct lysis of cancer cells through granule-mediated cytotoxicity (perforin/granzyme) and death receptor-mediated cytotoxicity (FasL/FasR, TRAIL/TRAIL-R).
03
Biological functions
Cell DeathImmune ResponseTumor Suppression
04
Disease associations
Cancer
05
Safety considerations
Cytokine Release Syndrome (CRS)On-target, off-tumor toxicityImmune-related adverse events (irAEs)Tumor lysis syndrome
06
Interacting drugs
Monoclonal Antibodies (e.g., Rituximab, Trastuzumab)
3 more in the full profile.
07
Biomarkers
PD-L1 expressionTumor Mutational Burden (TMB)Microsatellite Instability (MSI)Expression of target antigens (e.g., HER2, CD20)Immune cell infiltration
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