Cancer Cell (Oncolysis via Viral Replication)

Cancer cells, as a therapeutic target for oncolytic virotherapy, are characterized by their susceptibility to infection and destruction by certain viruses—either naturally occurring or genetically engineered—that preferentially replicate within tumor cells. This process, known as oncolysis via viral replication, leads to cell lysis and stimulation of an anti-tumor immune response. Selectivity for cancer cells is achieved through exploitation of tumor-specific receptor expression, defective antiviral pathways, and engineered viral specificity.

Other names

Tumor CellMalignant Cell

Selective infection and replication of oncolytic viruses leading to cell lysis and release of tumor-associated antigens, stimulating an anti-tumor immune response.