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Cancer Cell Lysis via Immunologic Cytotoxicity
- Molecular classification
- Functional Process, Immune Response, Cell Death
01
Overview
Cancer cell lysis via immunologic cytotoxicity refers to the destruction of cancer cells by components of the immune system, primarily through mechanisms that involve direct recognition and killing of tumor cells. This process is central to many forms of cancer immunotherapy, which aim to harness or enhance the body's natural immune responses to eliminate malignant cells. Key mechanisms include cytotoxic T lymphocytes (CTLs), natural killer (NK) cells, and immunogenic cell death (ICD).
- Other names
- Tumor cell killing by immune systemImmunogenic cell death (ICD)-mediated tumor lysisCancer cell destruction by CTLs and NK cells
02
Mechanism of action
Induction of cancer cell death through activation of immune effector cells (CTLs, NK cells, DNTs) and/or stimulation of immunogenic cell death (ICD)
03
Biological functions
Tumor cell lysisImmune cell activationAdaptive immune responseInnate immune response
04
Disease associations
CancerImmune evasionTumor microenvironment
05
Safety considerations
Cytokine release syndrome (CRS)Immune-related adverse events (irAEs)On-target/off-tumor toxicityTumor lysis syndrome
06
Interacting drugs
Immune checkpoint inhibitors (e.g., anti-PD-1, anti-PD-L1, anti-CTLA-4)
7 more in the full profile.
07
Biomarkers
Tumor infiltrating lymphocytes (TILs)PD-L1 expressionMicrosatellite instability (MSI)Tumor mutational burden (TMB)DAMPs (e.g., calreticulin, HMGB1, ATP)Interferon-gamma (IFN-γ) signature
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